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rmil12  (R&D Systems)


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    Structured Review

    R&D Systems rmil12
    POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with <t>rmIL12</t> and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.
    Rmil12, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rmil12/product/R&D Systems
    Average 93 stars, based on 4 article reviews
    rmil12 - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "PlexinA1 (PLXNA1) as a novel scaffold protein for the engineering of extracellular vesicles"

    Article Title: PlexinA1 (PLXNA1) as a novel scaffold protein for the engineering of extracellular vesicles

    Journal: Journal of Extracellular Vesicles

    doi: 10.1002/jev2.70012

    POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with rmIL12 and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.
    Figure Legend Snippet: POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with rmIL12 and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.

    Techniques Used: Luciferase, Incubation, Control, Dissection



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    rmil12  (R&D Systems)
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    R&D Systems rmil12
    POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with <t>rmIL12</t> and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.
    Rmil12, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/rmil12/product/R&D Systems
    Average 93 stars, based on 1 article reviews
    rmil12 - by Bioz Stars, 2026-03
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with rmIL12 and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.

    Journal: Journal of Extracellular Vesicles

    Article Title: PlexinA1 (PLXNA1) as a novel scaffold protein for the engineering of extracellular vesicles

    doi: 10.1002/jev2.70012

    Figure Lengend Snippet: POIs fused with PLXNA1 truncations maintained their activities. (a) Schematic diagram of NanoLuc luciferase‐based assay of HepG2 cells adding PLXNA1 (863‐1316) EVs loaded with L7AE and mRNA of NanoLuc‐C/DBOX. (b) Relative levels of NanoLuc mRNA in HepG2 cell groups absorbed the EVs double‐loaded with NanoLuc‐C/DBOX and L7AE and the EVs loaded with NanoLuc‐C/DBOX. Mean ± SD. n = 3. ** p < 0.01. (c) Relative light units (RLUs) were measured by NanoLuc luciferase‐based assay in the indicating HepG2 cell groups. Mean ± SD. n = 3. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (d) RLUs were measured by NanoLuc luciferase‐based assay in the indicating groups at different dosages. Mean ± SD. n = 3. (e) Detection of IFN‐γ secreted by mouse lymphocytes. The lymphocytes were incubated with rmIL12 and EV‐mIL12 at different dosages. EC50 and R squared of the line graphs were indicated. Mean ± SD. n = 3 in each dosage. (f) Mice bearing MC38 subcutaneous tumours were dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng), EVmIL12 (100 ng) and EVmIL12 (500 ng). The subcutaneous tumour volumes were measured every other day. Mean + SD. n = 6. ns p > 0.05, ** p < 0.01, **** p < 0.0001. (g) After dissection at Day 16th, the tumour volumes were measured. Mean ± SD. n = 6 in each group. ns p > 0.05, * p < 0.05, ** p < 0.01.

    Article Snippet: Mice bearing MC38 subcutaneous tumours were randomized into groups and dosed intratumour into flank tumour three times every other day (Day 0, Day 2 and Day 4) with control (PBS), rmIL12 (100 ng) (10051‐ML‐050/CF, R&D system, USA), EVmIL12 (100 ng) and EVmIL12 (500 ng).

    Techniques: Luciferase, Incubation, Control, Dissection